Vascular mechanisms involved in angiotensin II-induced venoconstriction in hypertensive rats

► Angiotensin II (Ang II)-induced constriction was evaluated in mesenteric venules and portal vein of hypertensive rats (SHR). ► In SHR portal vein, Ang II-constriction was reduced when compared to normotensive Wistar rats. ► AT2 receptor protein expression and mRNA levels were reduced in portal vein from SHR. ► In SHR, Ang II venoconstriction was mediated by AT1 receptors and was counterbalanced by kinin B2 receptor and COX metabolites. ► Different cellular and molecular mechanisms are involved in the venous control of normotensive and hypertensive rats.