Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis

- Leptin and a leptin receptor agonist peptide constitutively activate the NF-κB pathway in peripheral blood mononuclear cells, and the leptin receptor antagonist peptide Allo-aca reverses the process.
- In a mouse serum transfer rheumatoid arthritis model, Allo-aca added subcutaneously partially inhibits the proinflammatory effects of leptin.
- In a rat adjuvant-induced rheumatoid arthritis, Allo-aca reverses all inflammatory symptoms in early stages, but is only partially effective in a more advanced disease.