Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats

► Peripheral leptin was reported to attenuate estrogen deficiency-induced bone loss. ► Hypothalamic administration of leptin was reported to be antiosteogenic. ► We evaluated bone in ovx rats with increased hypothalamic leptin gene expression. ► Ovx resulted in severe osteopenia. ► Increasing hypothalamic leptin gene expression had no additional effect on bone.