Mimotopes of mutalysin-II from Lachesis muta snake venom induce hemorrhage inhibitory antibodies upon vaccination of rabbits

► Investigation of reactivity of a monoclonal antibody against continuous peptides from mutalysin-II. ► Identification of mutalysin-II peptide mimotopes using phage-display approach. ► Neutralization of hemorrhagic activity induced by Lachesis muta snake venom by peptide mimotope antibodies. ► Synthetic immunogens may be promising candidates for alternative therapeutic serum development.