کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836018 | 1066378 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway](/preview/png/10836018.png)
چکیده انگلیسی
Urotensin II (U-II) and its receptor are coexpressed in the heart and show various cardiovascular functions. However, the relationship between U-II and cardiac hormone atrial natriuretic peptide (ANP) is still unknown. The aim of the present study is to test whether U-II affects ANP secretion using in vitro perfusion experiments and in vivo studies. Human U-II (hU-II) (10â11, 5 Ã 10â11, 10â10, 5 Ã 10â10 M) stimulated ANP secretion from isolated perfused rat atria paced with high frequency (6.0 Hz). However, atrial contractility and translocation of extracellular fluid (ECF) did not change. An increase in ANP secretion by rat U-II was similar to that by hU-II; however, urotensin-related peptide showed no significant effect on ANP secretion. Pretreatment with urotensin receptor antagonist and inhibitor for phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), or protein kinase C (PKC) attenuated hU-II-induced ANP secretion from atria paced with high frequency, but an inhibitor for inositol triphosphate did not. Intravenous infusion of hU-II at a dose of 2.5 μM for 20 min increased plasma ANP level, along with increased heart rate and pulse pressure in anesthetized rats. Therefore, we suggest that U-II stimulates high stimulation frequency-induced ANP secretion partly through the urotensin receptor and the PLC/PI3K/PKC pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 31, Issue 1, January 2010, Pages 164-169
Journal: Peptides - Volume 31, Issue 1, January 2010, Pages 164-169
نویسندگان
Shan Gao, Amin Shah, Young Bin Oh, Woo Hyun Park, Suhn Hee Kim,