The effects of neurotensin on selected parameters of lipid metabolism in rats

15 nM/kg b.m. of neurotensin (NT) caused a significant inhibition of LMA within 30 min of administration and this effect persisted up for to the 240th minute of the experiment. A 15 nM/kg b.m. dose also caused a reduction in SLA which persisted up to the 120th minute. Sixty minutes after an intraperitoneal administration of NT a decrease in the cholesterol and NEFA levels and an increase in the TG and glycerol levels were observed. These effects were inhibited by the NTR2-blocker (levocabastine) and were not subject to change after an in vivo application of SR 48692.