کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836289 | 1066417 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reciprocal opioid-opioid interactions between the ventral tegmental area and nucleus accumbens regions in mediating μ agonist-induced feeding in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Feeding elicited by the μ-selective agonist, [d-Ala2, M-Phe4, Gly-ol5]-encephalin administered into the nucleus accumbens is blocked by accumbal pre-treatment with μ, δ1, δ2 and κ, but not μ1 opioid antagonists. Correspondingly, μ-agonist-induced feeding elicited from the ventral tegmental area is blocked by ventral tegmental area pre-treatment with μ and κ, but not δ opioid antagonists. A bi-directional opioid-opioid feeding interaction has been firmly established such that μ-agonist-induced feeding elicited from the ventral tegmental area is blocked by accumbal naltrexone, and that accumbal μ-agonist-induced feeding is blocked by naltrexone pre-treatment in the ventral tegmental area. To determine which opioid receptor subtypes mediate the regional bi-directional opioid-opioid feeding interactions between these two sites, the present study examined the dose-dependent ability of either general (naltrexone), μ (β-funaltrexamine), κ (nor-binaltorphamine) or δ (naltrindole) opioid antagonists administered into one site to block μ-agonist-induced feeding elicited from the other site. General, μ and κ, but not δ opioid receptor antagonist pre-treatment in the ventral tegmental area dose-dependently reduced μ-agonist-induced feeding elicited from the nucleus accumbens. General, μ and δ, and to a lesser degree κ, opioid receptor antagonist pre-treatment in the nucleus accumbens dose-dependently reduced μ-agonist-induced feeding elicited from the ventral tegmental area. Thus, multiple, but different opioid receptor subtypes are involved in mediating opioid-opioid feeding interactions between the nucleus accumbens and ventral tegmental area regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 4, April 2005, Pages 621-629
Journal: Peptides - Volume 26, Issue 4, April 2005, Pages 621-629
نویسندگان
Richard J. Bodnar, Nicole Lamonte, Yuriy Israel, Yakov Kandov, Tsippa F. Ackerman, Eleonora Khaimova,