کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836401 | 1066423 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacology of stomoxytachykinin receptor depends on second messenger system
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacology of stomoxytachykinin receptor depends on second messenger system Pharmacology of stomoxytachykinin receptor depends on second messenger system](/preview/png/10836401.png)
چکیده انگلیسی
STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as “insectatachykinins”, produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned STKR cDNA. Pronounced differences in pharmacology were observed between agonist-induced calcium and cyclic AMP responses. The results indicate that the pharmacological properties of STKR depend on its coupling to a unique second messenger system. Therefore, a model postulating the existence of multiple active receptor conformations is proposed. This article presents the first evidence that an insect peptide receptor with dual coupling properties to second messenger systems can display agonist-dependent functional differences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 1, January 2005, Pages 109-114
Journal: Peptides - Volume 26, Issue 1, January 2005, Pages 109-114
نویسندگان
Jeroen Poels, Ronald J. Nachman, Karl E. Ã
kerman, Hendrica B. Oonk, Felix Guerrero, Arnold De Loof, Anna E. Janecka, Herbert Torfs, Jozef Vanden Broeck,