Cross-resistance to dicyclanil in cyromazine-resistant mutants of Drosophila melanogaster and Lucilia cuprina

Cyromazine is an insect growth regulator insecticide with a novel mode of action, mainly used to control dipteran insects. Previously, cyromazine-resistant mutants of the Australian sheep blowfly Lucilia cuprina and the vinegar fly Drosophila melanogaster have been isolated following ethyl methanesulfonate mutagenesis and selection for resistance. Here, we show that these cyromazime-resistant mutants are cross-resistant to dicyclanil, an insect growth regulator compound with a similar chemical structure to cyromazine. Dicyclanil was recently introduced as a control agent of L. cuprina. Cross-resistance to the benzylphenylurea insecticide lufenuron was also assessed. Only one D. melanogaster cyromazine-resistant mutant is cross-resistant to lufenuron.