Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway

► CTX III inhibited the EGF-induced invasion and migration of MDA-MB-231 cells. ► CTX III reduced the EGF-induced activation of MMP-9. ► CTX III suppressed EGF-induced NF-κB nuclear translocation. ► CTX III abrogated the EGF-induced phosphorylation of EGFR, PI3K/Akt and ERK 1/2.