A sensitive assay for palytoxins, ovatoxins and ostreocins using LC-MS/MS analysis of cleavage fragments from micro-scale oxidation

► A novel sensitive LC-MS/MS screening assay for palytoxin and related compounds. ► Monitors substructures generated by periodate oxidation. ► Oxidation step combined with SPE sample concentration and cleanup. ► Able to be used on marine microalgae cultures, shellfish and fish flesh.