Characterization of brevetoxin metabolism in Karenia brevis bloom-exposed clams (Mercenaria sp.) by LC-MS/MS

► Several brevetoxin metabolites were characterized in the hard clam (Mercenaria sp.). ► Products of oxidation, hydrolysis and amino acid/fatty acid conjugation were found. ► Cysteine and taurine conjugates of brevetoxin were of highest abundance. ► Potential biomarkers of brevetoxin exposure in clams were identified.