کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10879969 1076886 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca
چکیده انگلیسی
Jararhagin is a metalloproteinase isolated from Bothrops jararaca snake venom, which has been extensively studied. These studies showed its involvement on most of the systemic and local damaging effects of snakebite envenomings. In this review we comment on the major targets of jararhagin as the vascular endothelium, platelets and coagulation factors and also its action on other cell systems as inflammatory cells and their mediators, cancer and cell signaling. The mechanisms of jararhagin action are discussed together with structural features essential for the expression of its biological activities. The studies reviewed here denote jararhagin as a prototype for studies of snake venom metalloproteinases, bringing new insights into cellular-matrix interactions and adding for the improvement of snakebite treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 60, Issue 3, 1 September 2012, Pages 280-289
نویسندگان
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