Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis)

► A recombinant disintegrin, r-viridistatin 2, from the Prairie rattlesnake was cloned, expressed and isolated. ► r-Viridistatin 2 was able to inhibit the adhesion of 5 different cancer cell lines to various extracellular matrices. ► r-Viridistatin 2 effectively inhibited tumor colonization in mice by 71%.