A pro-inflammatory profile of endothelial cell in Lonomia obliqua envenomation

► Lonomia obliqua venom induces in vivoendothelial activation increasing l-selectin and VCAM-1 expression. ► L. obliqua venom affects actin cytoskeleton dynamics in endothelial cells. ► The venom induces NF-kB activation and increase COX-2, iNOS, HO-1 expression in endothelial cells. ► The venom induces a pro-inflammatory profile increasing endothelial MMP-2 and MMP-9 secretion. ► The inflammatory effect on vascular endothelium can contribute for local and systemic effects.