کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10880314 1076955 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of a F(ab′)2 scorpion antivenom in healthy human volunteers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Pharmacokinetics of a F(ab′)2 scorpion antivenom in healthy human volunteers
چکیده انگلیسی
This paper presents the first study of F(ab′)2 scorpion antivenom pharmacokinetics in humans. We have studied the pharmacokinetics of an antiscorpion venom preparation (Alacramyn™) in eight human healthy volunteers. The fabotherapic was administered as a 47.5 mg i.v. bolus. Blood samples were drawn at 0, 5, 15, 30, 45, 60, 90, 120, 180 and 360 min after antivenom administration. Subsequently, the volunteers made seven visits to the hospital. Four of them at 24 h intervals, one at day 10, and one at day 21. We measured antivenom plasmatic concentrations using a specific high sensitivity ELISA method for F(ab′)2. The time course of F(ab′)2 in serum of seven subjects was well described by a lineal combination of three exponential components; a four exponential component model was necessary to fit the eighth subject. The most significant antivenom pharmacokinetic parameters determined were: AUC∞=596.9 (369.3, 891.2) mg h l−1; Vc=3.1 (2.3, 4.3) l; Vss=15.4 (12.8, 39.9) l; MRT=250.0 (218.8, 310.2) h; CL=96.6 (58.0, 139.2) ml h−1; t1/2,τ1 (also called t1/2,α)=0.25 (0.13, 0.37) h; t1/2,τz (corresponding to the slowest component)=161.3 (141.0, 212.0) h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 46, Issue 7, 1 December 2005, Pages 797-805
نویسندگان
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