Enhancement of differentiation efficiency of hESCs into vascular lineage cells in hypoxia via a paracrine mechanism

► First report about the relationship between HIF-1α expression and hESC differentiation. ► First verification which enhanced hESC differentiation efficacy under hypoxic condition was caused by intrinsic up-regulation of pro-angiogenic factors along with HIF-1α expression. ► Give a specific clue about micro environmental change on differentiation. ►