CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells

► CCR1 is one of the few chemokine receptors highly expressed in ADSCs. ► Expression of OCT4, SOX2 and NANOG correlates with CCR1 expression in ADSCs. ► Expression of CCR1, SOX2, OCT4 and NANOG is elevated upon CCL5 signaling. ► CCL5 signaling stimulates NFκB transcriptional activity and migration of ADSCs. ► CCL5/CCR1 axis is biologically functional in ADSCs.