HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR/p70S6K signaling pathway

► HMGA2 is an architectural transcription factor that alters chromatin structure. ► HMGA2 induced a PI3K/AKT/mTOR/p70S6K cascade. ► Overexpression of HMGA2 activated cell cycle related genes. ► Overexpression of HMGA2 inhibited CDK inhibitors. ► Overexpression of HMGA2 enhances proliferation and reduces the SA-β-gal activity.