Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

► Mouse bone marrow stromal cells and Bone express only SVCT2 and not SVCT1. ► SVCT2 plays an important role in the osteogenic differentiation of BMSCs. ► Down-regulation of SVCT2 significantly reduces BMSCs osteogenesis. ► The expression of the SVCT2 is modulated by redox reaction. ► SVCT2 is down-regulated with age in mouse bone.