Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells

► hES cells express TRKB and TRKC genes that are important for single hES cell survival. ► The expression of the TRKC gene is dependent on SOX2 expression. ► The TRKC gene contains conserved SOX binding sites within the TRKC regulatory region. ► SOX2 binds to and regulates expression of the TRKC gene.