کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10897324 | 1083844 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multi-state relative survival modelling of colorectal cancer progression and mortality
ترجمه فارسی عنوان
مدلسازی بقای نسبی چند کشور از پیشرفت سرطان کولورکتال و مرگ و میر
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Accurate identification of factors associated with progression of colorectal cancer remains a challenge. In particular, it is unclear which statistical methods are most suitable to separate the effects of putative prognostic factors on cancer progression vs cancer-specific and other cause mortality. To address these challenges, we analyzed 10 year follow-up data for patients who underwent curative surgery for colorectal cancer in 1985-2000. Separate analyses were performed in two French cancer registries. Results of three multivariable models were compared: Cox model with recurrence as a time-dependent variable, and two multi-state models, which separated prognostic factor effects on recurrence vs death, with or without recurrence. Conventional multi-state model analyzed all-cause mortality while new relative survival multi-state model focused on cancer-specific mortality. Among the 2517 and 2677 patients in the two registries, about 50% died without a recurrence, and 28% had a recurrence, of whom almost 90% died. In both multi-state models men had significantly increased risk of cancer recurrence in both registries (HRÂ =Â 0.79; 95% CI: 0.68-0.92 and HRÂ =Â 0.83; 95% CI: 0.71-0.96). However, the two multi-state models identified different prognostic factors for mortality without recurrence. In contrast to the conventional model, in the relative survival analyses gender had no independent association with cancer-specific mortality whereas patients diagnosed with stage III cancer had significantly higher risks in both registries (HRÂ =Â 1.67; 95% CI: 1.27-2.22 and HRÂ =Â 2.38; 95% CI: 1.29-3.27). In conclusion, relative survival multi-state model revealed that different factors may be associated with cancer recurrence vs cancer-specific mortality either after or without a recurrence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Epidemiology - Volume 39, Issue 3, June 2015, Pages 447-455
Journal: Cancer Epidemiology - Volume 39, Issue 3, June 2015, Pages 447-455
نویسندگان
Séverine Gilard-Pioc, Michal Abrahamowicz, Amel Mahboubi, Anne-Marie Bouvier, Olivier Dejardin, Ella Huszti, Christine Binquet, Catherine Quantin,