کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10897347 | 1083845 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Birth weight and subsequent risk of cancer
ترجمه فارسی عنوان
وزن تولد و خطر ابتلا به سرطان
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کلمات کلیدی
وزن تولد، نئوپلاسم ها، نئوپلاسمهای پستان، نئوپلاسم های کولورکتال، سرطان ریه، نئوپلاسم تخمدان، سرطان آندومتر، لوسمی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Background: We aimed to determine the association between self-reported birth weight and incident cancer in the Women's Health Initiative Observational Study cohort, a large multiethnic cohort of postmenopausal women. Methods: 65,850 women reported their birth weight by category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and â¥10 lbs). All self-reported, incident cancers were adjudicated by study staff. We used Cox proportional hazards regression to estimate crude and adjusted hazard ratios (aHR) for associations between birth weight and: (1) all cancer sites combined, (2) gynecologic cancers, and (3) several site-specific cancer sites. Results: After adjustments, birth weight was positively associated with the risk of lung cancer (p = 0.01), and colon cancer (p = 0.04). An inverse trend was observed between birth weight and risk for leukemia (p = 0.04). A significant trend was not observed with breast cancer risk (p = 0.67); however, women born weighing â¥10 lbs were less likely to develop breast cancer compared to women born between 6 lbs-7 lbs 15 oz (aHR 0.77, 95% CI 0.63, 0.94). Conclusion: Birth weight category appears to be significantly associated with the risk of any postmenopausal incident cancer, though the direction of the association varies by cancer type.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Epidemiology - Volume 38, Issue 5, October 2014, Pages 538-543
Journal: Cancer Epidemiology - Volume 38, Issue 5, October 2014, Pages 538-543
نویسندگان
Cassandra N. Spracklen, Robert B. Wallace, Shawnita Sealy-Jefferson, Jennifer G. Robinson, Jo L. Freudenheim, Melissa F. Wellons, Audrey F. Saftlas, Linda G. Snetselaar, JoAnn E. Manson, Lifang Hou, Lihong Qi, Rowan T. Chlebowski, Kelli K. Ryckman,