کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10897405 | 1083846 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Life expectancy estimates as a key factor in over-treatment: The case of prostate cancer
ترجمه فارسی عنوان
امید به زندگی به عنوان یک عامل کلیدی در درمان بیش از حد تخمین زده می شود: مورد سرطان پروستات
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کلمات کلیدی
سرطان پروستات، بیش از حد تشخیص، بیش از درمان، همبودی، وجود همزمان دو بیماری، امید به زندگی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Objective: To estimate the magnitude of over-diagnosis and of potential and actual over-treatment regarding prostate cancer, taking comorbidities into account. Materials and methods: We used a sample collected by the French cancer registries of 1840 cases (T1: 583; T2: 1257) diagnosed in 2001. The proportion of over-diagnosed and over-treated patients was estimated by comparing life expectancy (LE), including or not comorbidities, with natural LE with cancer, using several assumptions from the literature. We distinguished potential and actual over-treatment according to the treatment that patients actually received. Results: Among patients with T1 tumors the proportion of potential over-treatment using LE adjusted for comorbidity varied from 29.5% to 53.5%, using LE adjusted on comorbidities, and varied from 9.3% to 22.2% regarding actual over-treatment. Between 7.7% and 24.4% of patient's receiving a radical prostatectomy, and between 30.8% and 62.5% of those receiving radiotherapy, were over-treated. Among patients with T2 tumors, the proportions of potential and actual over-treatment were 0.9% and 2.0%. Two per cent of patients receiving a radical prostatectomy and 4.9% of those receiving radiotherapy were over-treated. Comorbidities dramatically increased these proportions to nearly 100% of patients, with more than two comorbidities being potentially over-treated and around 33% actually over-treated. Conclusions: According to the French incidence, 3200-4800 French patients may be over-treated, among whom a large proportion of patients had comorbidities. The real issue is to offer the most appropriate treatment to people with low-grade tumors and comorbidities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Epidemiology - Volume 37, Issue 4, August 2013, Pages 462-468
Journal: Cancer Epidemiology - Volume 37, Issue 4, August 2013, Pages 462-468
نویسندگان
Cyrille Delpierre, Sébastien Lamy, Michelle Kelly-Irving, Florence Molinié, Michel Velten, Brigitte Tretarre, Anne-Sophie Woronoff, Antoine Buemi, Bénédicte Lapôtre-Ledoux, Simona Bara, Anne-Valérie Guizard, Marc Colonna, Pascale Grosclaude,