کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10908616 | 1087793 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Three-fold higher frequency of circulating chronic lymphocytic leukemia-like B-cell clones in patients with Ph-Myeloproliferative neoplasms
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
By analyzing 82 patients with PhâMPN and 100 age-matched healthy individuals we demonstrate that MPN patients have an almost threefold higher prevalence of, typically low-count, CLL-like monoclonal B lymphocytosis (MBL) compared to normal adults. The clone size remained unaltered during the disease course and unaffected by the administration of hydroxycarbamide, whereas no patient with PhâMPN/MBL progressed to CLL during a median follow up of 4 years. Monoclonal B cells in PhâMPN/MBL patients and normal individuals and in four more patients with coexistence of overt CLL and MPN displayed heterogeneous biological characteristics, while the JAK2V617F mutation was absent in isolated lymphocytes from PhâMPN patients with coexistence of CLL. Despite its clinical and biological variability, the increased incidence of MBL in PhâMPN patients along with the one reported for CLL further enforces the notion of a shared pathophysiology among the two malignancies via a common genetic link and/or microenviromental interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 39, Issue 11, November 2015, Pages 1159-1165
Journal: Leukemia Research - Volume 39, Issue 11, November 2015, Pages 1159-1165
نویسندگان
Paraskevi Miltiades, Eleftheria Lamprianidou, Iliana K. Kerzeli, Evangelia Nakou, Spyros I. Papamichos, Emmanuil Spanoudakis, Ioannis Kotsianidis,