کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10908694 1087800 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)
چکیده انگلیسی
We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥4 versus ≤1) was associated with increased 30-day mortality (OR = 9.98, 95% CI = 1.18-84.13), lower odds of complete remission status (OR = 0.20, 95% CI = 0.06-0.65), and higher overall mortality (HR = 2.13, 95% CI = 1.15-3.92). Inappropriate medication use (classified according to Beers criteria) was not significantly associated with clinical outcomes. Polypharmacy warrants further study as a modifiable marker of vulnerability among older adults with AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 10, October 2014, Pages 1184-1190
نویسندگان
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