کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10908709 1087801 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation between FLT3-ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Correlation between FLT3-ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias
چکیده انگلیسی
Internal tandem duplications (ITD) of FLT3 gene occur in about a third of acute promyelocytic leukemias (APL). We investigated the patterns of blood count, surface antigen, expression, chromosome aberrations, PML-RARa isoform, gene expression profile (GEP) and survival in 34 APL patients according to FLT3-ITD status. 97% had a t(15;17) and all of them carried PML-RARa gene fusion, 8 (23.5%) had a FLT3-ITD mutation. Presence of ITD was associated with higher Hb and WBC levels, bcr3 isoform, CD34 expression, CD2 or CD2/CD34 expression. In a multivariate analysis, Hb > 9.6 g/dL and WBC ≥ 20 × 109/L were important factors for predicting ITD presence. GEP showed that FLT3-ITD carriers clustered separately, even when as few as 5 genes were considered. This study provides further evidence that FLT3-ITDs carriers constitute a biologically distinct group of APL patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 39, Issue 2, February 2015, Pages 131-137
نویسندگان
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