کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10908737 | 1087801 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The hENT1 and DCK genes underlie the decitabine response in patients with myelodysplastic syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The hENT1 and DCK genes underlie the decitabine response in patients with myelodysplastic syndrome The hENT1 and DCK genes underlie the decitabine response in patients with myelodysplastic syndrome](/preview/png/10908737.png)
چکیده انگلیسی
Decitabine is approved for the treatment of MDS, but resistance to this agent is common. To determine the mechanisms underlying decitabine resistance, we measured the mRNA expression of metabolism (hENT1, DCK, CDA) and apoptosis (BCL2L10) genes and found that the hENT1 mRNA level was significantly higher in response compared with non-response patients (PÂ =Â 0.004). Furthermore, the DCK level was significantly reduced for relapse (PÂ =Â 0.012) compared with those with continued marrow CR (PÂ =Â 0.222). These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 39, Issue 2, February 2015, Pages 216-220
Journal: Leukemia Research - Volume 39, Issue 2, February 2015, Pages 216-220
نویسندگان
Ping Wu, Suxia Geng, Jianyu Weng, Chengxin Deng, Zesheng Lu, Chengwei Luo, Xin Du,