کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10908866 1087815 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?
چکیده انگلیسی
C-myc protein expression has been studied in mature B-cell lymphomas and overexpression has been associated with poor prognosis. We sought to determine the prognostic significance of c-myc protein expression in B-ALL. We found ≥20% c-myc expression to predict risk of persistent disease in all age groups (odds ratio 7.487, p = 0.013). There was no statistically significant association between c-myc expression and risk of relapse or death in our study. Routine c-myc immunostaining may help identify higher risk patients and guide management of B-ALL. Additional studies are needed to further determine the molecular mechanisms and role of c-myc expression in B-ALL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 9, September 2014, Pages 1061-1066
نویسندگان
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