کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10908890 | 1087816 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characteristics and prognosis analysis of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide as the front-line therapy
ترجمه فارسی عنوان
مشخصات و پیش آگهی تجزیه و تحلیل اضطراب غیر کروموزوم اضافی در لوکمی پرومیلوسیتی حاد که به تازگی تشخیص داده شده است درمان شده با ترشح آرسنیک به عنوان خط مقدم درمان
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کلمات کلیدی
لوسمی پرومیلوسیتیک حاد، اختلالات سیتوژنتیک اضافی، ترانس اکسید آرسنیک، پیش بینی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Currently, there are few studies that address the prognostic significance of baseline additional chromosomal abnormalities (ACAs) in newly diagnosed acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (ATO) as the front-line therapy. A series of 271 consecutive APL patients has been cytogenetically investigated between 2004 and 2011 in our institution. The incidence of ACAs was 27% (46/172) in APL cases with t(15;17). Trisomy 8 was the most recurrent abnormality, accounting for 30% (14/46) of patients with ACAs, followed by +21 (7%, 3/46) and â7/7q (7%, 3/46). Nine cases (14.1%) were found to have additional balanced translocation aberrations, most of them are new and non-recurrent. Treatment protocols consisted of all-trans retinoic acid (ATRA) and chemotherapy with or without the ATO therapy. Overall, patients with and without ACAs had similar complete remission (CR) rates (94% and 98%, respectively, PÂ =Â 0.344). With a median follow-up of 41 months, univariate analysis showed that ACAs did not show any prognostic significance in relapse-free survival (RFS) and overall survival (OS). In addition, ATO treatment was an independent favorable predictor for RFS. Thus, this data provides insights into cytogenetic features of APL, and suggests that ATO-based combination therapy improved RFS in de novo APL patients, while ACAs had no impact on prognosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 11, November 2013, Pages 1451-1456
Journal: Leukemia Research - Volume 37, Issue 11, November 2013, Pages 1451-1456
نویسندگان
Yinjun Lou, Shanshan Suo, Hongyan Tong, Xingnong Ye, Yungui Wang, Zhimei Chen, Wenbin Qian, Haitao Meng, Wenyuan Mai, Jian Huang, Yin Tong, Jie Jin,