کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10908905 1087816 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome
چکیده انگلیسی
Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n = 109), AML (n = 47) and in controls (n = 24). TL was lower in MDS patients than in controls (p < 0.001) and higher in L-MDS (low, intermediate-1 IPSS, p < 0.01) respect H-MDS (high, intermediate-2 IPSS, p < 0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p < 0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 11, November 2013, Pages 1538-1544
نویسندگان
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