کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10908984 | 1087820 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy controls. The frequency of CD1d+/CD19+ cells, CD1d staining intensity and CD1d transcript levels increased with the disease stage. CD1d expression was positively associated with ZAP-70 and CD38 expressions as well as with unfavourable cytogenetic changes. We established the relationship between high CD1d expression and shorter time to treatment and overall survival. We observed that CD1d expression in individual patients significantly changed over time. The percentage of CD1d+/CD19+ cells inversely correlated with the percentage of iNKT cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 4, April 2014, Pages 435-442
Journal: Leukemia Research - Volume 38, Issue 4, April 2014, Pages 435-442
نویسندگان
Agnieszka Bojarska-Junak, Iwona Hus, Sylwia Chocholska, Waldemar Tomczak, Justyna WoÅ, PaweÅ Czubak, LechosÅaw Putowski, Jacek RoliÅski,