کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909049 | 1087823 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: Experience in a Chinese single institution
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: Experience in a Chinese single institution Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: Experience in a Chinese single institution](/preview/png/10909049.png)
چکیده انگلیسی
T-cell large granular lymphocyte leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder. Available reported data on the treatment regimens of this disease are variable and limited due to low number of patients. We analyzed the efficiency of cyclosporine A (CsA) in the treatment of 28 patients with T-LGLL. The overall response rate (ORR) was 82.1% with hematologic complete remission (HCR) rate of 57.1%. The median time to response (TTR) was 1.8 months and treatment duration with CsA-based regimens was 34.5 months. CsA shows low and manageable toxicity during treatment. Twenty-one patients survived with a median follow-up time of 42.0 months. Our results indicate that CsA is efficacious and safe in the treatment of T-LGLL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 5, May 2013, Pages 547-551
Journal: Leukemia Research - Volume 37, Issue 5, May 2013, Pages 547-551
نویسندگان
Xin Zhao, Kang Zhou, Liping Jing, Li Zhang, Guangxin Peng, Yang Li, Lei Ye, Jianping Li, Huihui Fan, Yuan Li, Fengkui Zhang,