کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909061 1087824 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential
چکیده انگلیسی
Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. Patients mobilizing more than 60,000 CD34+ cells/ml had shorter overall survival (OS; P = 0.0274), shorter time to progression (TTP; P = 0.0014), and a higher relapse rate (P = 0.0177). High levels of CD34+ cells were an independent marker for shorter OS and TTP in a multivariate analysis. These data suggest that ASCT is associated with unfavorable outcome in AML patients with high levels of mobilized peripheral CD34+ cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 11, November 2012, Pages 1325-1329
نویسندگان
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