کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909070 1087824 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection
چکیده انگلیسی
We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p = 0.019), had more complex cytogenetics (p = 0.015), and more often had 7q deletion or monosomy 7 (p = 0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p = 0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 11, November 2012, Pages 1376-1379
نویسندگان
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