کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909181 | 1087839 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features](/preview/png/10909181.png)
چکیده انگلیسی
The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 3, March 2012, Pages 293-298
Journal: Leukemia Research - Volume 36, Issue 3, March 2012, Pages 293-298
نویسندگان
Jaqueline Carvalho de Oliveira, Carlos Alberto Scrideli, MarÃa Sol Brassesco, Andressa Gois Morales, Julia Alejandra Pezuk, Rosane de Paula Queiroz, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone,