کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909185 1087839 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minimal residual disease monitoring based on FLT3 internal tandem duplication in adult acute myeloid leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Minimal residual disease monitoring based on FLT3 internal tandem duplication in adult acute myeloid leukemia
چکیده انگلیسی
FLT3 internal tandem duplication (FLT3-ITD) is usually considered as a bad marker for minimal residual disease (MRD) follow-up in acute myeloid leukemia (AML). Our objective was to evaluate the suitability of FLT3-ITD as a target for MRD detection by real-time quantitative PCR, in comparison with two other molecular MRD markers, NPM1 mutation and WT1 overexpression, in 20 adult AML patients treated in Acute Leukemia French Association (ALFA) trials. Overall, these 3 MRD markers showed comparable kinetics in 17/20 (85%) cases. Furthermore, we found that FLT3-ITD MRD levels after induction chemotherapy are predictive of complete remission duration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 3, March 2012, Pages 316-323
نویسندگان
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