کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909349 | 1087853 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Masked t(15;17) APL with the insertion of PML-RARα fusion gene in 4q21
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Masked t(15;17) APL with the insertion of PML-RARα fusion gene in 4q21 Masked t(15;17) APL with the insertion of PML-RARα fusion gene in 4q21](/preview/png/10909349.png)
چکیده انگلیسی
Most cases of acute promyelocytic leukemia (APL) are characterized by the reciprocal translocation t(15;17); however, several complex variant translocations have also been reported. Here we report complex cytogenetic abnormalities without t(15;17) assayed by the G-banding method in a 62-year-old woman with the typical morphology and clinical features of APL. Based on spectral karyotyping and FISH analyses, we confirm the insertion of a cryptic chromosomal segment containing the PML/RARα fusion gene. The patient achieved complete remission after treatment with all-trans retinoic acid (ATRA) alone. Although the mechanism of this cryptic variant insertion is not known, we conclude that the insertion of PML-RARα fusion into 4q21 seems not to alter the effectiveness of treatment with ATRA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 11, November 2009, Pages 1552-1555
Journal: Leukemia Research - Volume 33, Issue 11, November 2009, Pages 1552-1555
نویسندگان
Kouichi Haraguchi, Nobuhito Ohno, Masahito Tokunaga, Mayumi Tokunaga, Takahiro Itoyama, Minako Gotoh, Masafumi Taniwaki, Hirohito Tubouchi,