Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF

► Inhibition of NHE1 by cariporide in K562 decreases the pHi. ► VEGF secretion by K562 is inhibited upon cariporide treatment. ► HUVECs proliferation and migration are inhibited partially through decreased VEGF. ► In vitro tube formation is also inhibited partially by VEGF down-regulation. ► Microvessel density is decreased in cariporide treated K562 xenograft tumor.