کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909421 1087858 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia
چکیده انگلیسی
Bleeding in acute promyelocytic leukemia (APL) is mainly associated with disseminated intravascular coagulation and hyperfibrinolysis. Annexin II (Ann II) is a co-receptor for plasminogen and tissue plasminogen activator (tPA). This study demonstrates that abnormally high levels of Ann II expression in APL cells increase the production of plasmin. Hyperfibrinolysis could be corrected by all-trans retinoic acid (ATRA) or ATRA plus arsenic trioxide therapy in patients with APL. SiRNA targetting Ann II caused a decrease in tPA-dependent plasmin generation, while Ann II cDNA transfectant stimulated plasmin production. These results suggest that Ann II play an important role in hyperfibrinolysis in APL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 7, July 2011, Pages 879-884
نویسندگان
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