کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909477 | 1087861 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smoke
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smoke Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smoke](/preview/png/10909477.png)
چکیده انگلیسی
We assess the possible genotoxic effect of maternal smoking on amniotic fluid cells, based on the presence of an increasing of structural abnormality of the 11q23 band bearing the MLL gene rearrangements. In this observational and prospective study cultured amniocytes were obtained from 20 control and 20 women who smoke (>10 cigarettes/day for >10 years and during pregnancy). We performed fluorescence in situ hybridization (FISH) analysis in amniocytes. Comparison of FISH data between smoker and control groups showed statistical significance for the MLL gene rearrangements. Epidemiologic studies, including a large series of patients, will be needed to determine whether the offspring of parents who smoke have an increased lifetime risk of leukemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 8, August 2011, Pages 1066-1069
Journal: Leukemia Research - Volume 35, Issue 8, August 2011, Pages 1066-1069
نویسندگان
Rosa Ana de la Chica, Carmen Mediano, Marta Salido, Blanca Espinet, Josep Maria Manresa, Francesc Solé,