کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909648 | 1087930 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial gene knockout HL60Ï0 cells show preferential differentiation into monocytes/macrophages
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mitochondrial gene knockout HL60Ï0 cells show preferential differentiation into monocytes/macrophages Mitochondrial gene knockout HL60Ï0 cells show preferential differentiation into monocytes/macrophages](/preview/png/10909648.png)
چکیده انگلیسی
This study compares the differentiation potential of mitochondrial gene knockout (Ï0) and parental HL60 cells in response to 1.25% dimethylsulfoxide (DMSO) and 10Â nM phorbol myristate acetate (PMA). Compared to HL60 cells, undifferentiated HL60Ï0 cells showed partial monocyte/macrophage differentiation, with increased CD11c and CD14 expression, decreased CD71 expression, and weak non-specific esterase staining. Differentiation along the monocyte/macrophage pathway (PMA) was more pronounced in HL60Ï0 than parental HL60 cells with increased CD11c and CD14 expression and stronger non-specific esterase staining. DMSO-exposure resulted in a poorly differentiated nuclear morphology, small respiratory burst and marginal up-regulation of CD15 expression in HL60Ï0 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 10, October 2005, Pages 1163-1170
Journal: Leukemia Research - Volume 29, Issue 10, October 2005, Pages 1163-1170
نویسندگان
Patries M. Herst, D. Matt Levine, Michael V. Berridge,