کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909711 | 1087933 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional T-cell anergy in a case of persistent polyclonal B-cell lymphocytosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Functional T-cell anergy in a case of persistent polyclonal B-cell lymphocytosis Functional T-cell anergy in a case of persistent polyclonal B-cell lymphocytosis](/preview/png/10909711.png)
چکیده انگلیسی
The T-cell population of a patient with persistent polyclonal B-cell lymphocytosis (PPBL) presenting with an intermittent Epstein-Barr virus (EBV)-associated disease was studied. Unstimulated T-cells did not express CD40 ligand (CD40L), whereas activation with IL-2 led to expression of this costimulatory molecule. CD40L expression was inhibited upon incubation with the supernatant of an EBV-positive B-cell line (SM) which had been grown spontaneously from the patient's peripheral blood cells. The supernatant of SM cells effectively inhibited cytotoxic T-cells. Elevated levels of IL-10, TNF-alpha and soluble CD40 were found in the supernatant of SM cells. Additionally, enhanced levels of LMP-1 protein were detected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 12, December 2005, Pages 1479-1488
Journal: Leukemia Research - Volume 29, Issue 12, December 2005, Pages 1479-1488
نویسندگان
Manfred Mitterer, Andrea J. Lanthaler, Eveline U. Irschick, Hartmut Engelmann, Clara Larcher, Hartwig P. Huemer,