کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909729 1087935 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia
چکیده انگلیسی
We present our first experiences with determination of minimal residual disease (MRD) based on patient specific Flt3-ITD (internal tandem duplication) mutations. We analysed MRD status of 11 AML patients in a retrospective investigation and its potential impact on the follow up of these patients. In five out of six patients with a positive Flt3-ITD based MRD status a relapse of AML was observed in the follow up while one patient lacks a clinical relapse so far. In contrast, four out of five patients with a negative MRD status remain free of disease. One of these patients relapsed with a switch of FAB subtype including loss of Flt3-ITD mutation. Furthermore, in one patient we could identify a Flt3-ITT (internal tandem triplication mutation).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 7, July 2005, Pages 849-853
نویسندگان
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