کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10911458 | 1088312 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Haplotypes defined by multiple loci may be more precise and useful than genotypes in providing risk estimates for particular cancers. Diplotype is defined as a specific combination of two haplotypes. A Chinese case-control analysis comprising 370 cases and 388 controls was conducted to evaluate the effects of the high-risk diplotype predefined as PPP1R13L rs1970764AA-CD3EAP rs967591GG-ERCC1 rs11615AA among Caucasians and three SNPs alone or other haplotypes combined for lung cancer risk. Both the variant G-allele of PPP1R13L rs1970764 and the variant A-allele of CD3EAP rs967591 were significantly over-represented among cases (PÂ =Â 0.03 and PÂ =Â 0.002, respectively). The variant GG-homozygotes of PPP1R13L rs1970764 had increased risk [GG versus AA: adjusted OR (95% CI)Â =Â 1.30 (1.04-1.62), PÂ =Â 0.02]. The carriers of variant A-allele of CD3EAP rs967591 also presented increased risk [AA versus GG: adjusted OR (95% CI)Â =Â 1.40 (1.12-1.75), PÂ =Â 0.004; AG versus GG: adjusted OR (95% CI)Â =Â 1.47 (1.05-2.07), PÂ =Â 0.03 and AGÂ +Â AA versus GG: adjusted OR (95% CI)Â =Â 1.26 (1.07-1.48), PÂ =Â 0.005]. Interaction between CD3EAP rs967591 and smoking duration was observed (PÂ =Â 0.003). Only haplotype 1 (the common haplotype) defined as PPP1R13L rs1970764G-CD3EAP rs967591A-ERCC1 rs11615G showed marginally increased risk [OR (95% CI)Â =Â 1.38 (1.09-1.75), PÂ =Â 0.009] after Bonferroni correction. The frequency of the high-risk diplotype predefined among Caucasians was 1% in controls and no significant evidence of the diplotype distribution between cases and controls was detected in present study. In conclusion, we found that variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer, but the high-risk diplotype predefined among Caucasians was rare and the diplotype is unlikely to confer lung cancer risk in a Chinese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 76, Issue 3, June 2012, Pages 286-291
Journal: Lung Cancer - Volume 76, Issue 3, June 2012, Pages 286-291
نویسندگان
Jiaoyang Yin, Ulla Vogel, Yegang Ma, Huiwen Wang, Chunhong Wang, Duohong Liang, Li Yue, Jian Ma, Xinxin Li,