کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10911484 | 1088312 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic impact of education level of patients with advanced non-small cell lung cancer enrolled in clinical trials
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
In Italian patients enrolled in four randomized trials of first-line chemotherapy for advanced NSCLC, high education was significantly more frequent among younger patients, and was associated with lower proportion of PS2 patients. Education level did not significantly affect number of chemotherapy cycles received. Overall survival was longer in patients with high education, after adjustment for PS and other prognostic factors. The exact underlying mechanisms of the independent prognostic role of education level are substantially unknown, but lead-time bias (anticipation in diagnosis and time to inclusion in the trial), differences in adherence to care outside the trial procedures, differences in comorbidities and life-style factors may all contribute.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 76, Issue 3, June 2012, Pages 457-464
Journal: Lung Cancer - Volume 76, Issue 3, June 2012, Pages 457-464
نویسندگان
Massimo Di Maio, Simona Signoriello, Alessandro Morabito, Antonio Rossi, Paolo Maione, FrancoVito Piantedosi, Domenico Bilancia, Silvio Cigolari, Santi Barbera, Vittorio Gebbia, Bruno Daniele, Sergio Federico Robbiati, Alfonso Illiano, Anna Ceribelli,