کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10911845 1088393 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Octreotide treatment for paraneoplastic intestinal pseudo-obstruction complicating SCLC
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Octreotide treatment for paraneoplastic intestinal pseudo-obstruction complicating SCLC
چکیده انگلیسی
Small cell lung cancer (SCLC) is often associated with paraneoplastic neurological syndromes like intestinal pseudo-obstruction. This syndrome is characterized by dysmotility of the bowel without mechanical obstruction. The pathogenesis of the syndrome is thought to involve autoimmune mechanisms with production of antineuronal antibodies and enteric neuronal degeneration. We report a patient with severe constipation as a clinical presentation of a paraneoplastic intestinal pseudo-obstruction complicating SCLC, who was successfully treated with the somatostatin analogue octreotide. This may be explained by effects of hormone-like substances from the tumor directly inhibiting the gut motility, rather than by autoimmune mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 48, Issue 1, April 2005, Pages 137-140
نویسندگان
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