کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914960 | 1089527 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of background DNA damage in a Turkish population measured by means of the cytokinesis-block micronucleus cytome assay
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of background DNA damage in a Turkish population measured by means of the cytokinesis-block micronucleus cytome assay Evaluation of background DNA damage in a Turkish population measured by means of the cytokinesis-block micronucleus cytome assay](/preview/png/10914960.png)
چکیده انگلیسی
This study aimed to determine the background incidence of micronuclei (MN), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) in the peripheral blood lymphocytes of a population in the province of Ãanakkale, Turkey. Seventy-one individuals living under similar socio-economic conditions, not exposed to an X-ray examination during the last six months, receiving no medical treatment and not involved in agricultural activities were evaluated. In addition to genetic end-points, the cytokinesis-block proliferation index (CBPI) was determined. MN and NBUD frequencies gradually increased with age. MN frequencies of the older group were â¼7 fold higher than those of the younger group. Multiple linear regression analysis showed that apart from age, no significant effects of various confounding factors on MN and NBUD were observed. NPB frequencies were affected by gender. In the present study, no statistically significant effect was found of smoking on the genetic end-points evaluated, which agrees with results from other studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 757, Issue 1, 18 September 2013, Pages 23-27
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 757, Issue 1, 18 September 2013, Pages 23-27
نویسندگان
Mahmut CoÅkun, Akın Ãayır, Münevver CoÅkun, Hayal Tok,