Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line

- The effects of furazolidone on S phase cell cycle arrest of HepG2 were studied.
- Furazolidone can suppress the cell proliferation of HepG2 in vitro.
- Activated p-p38 can inhibit p-JNK activity in HepG2 induced by furazolidone.
- FZD induces cell cycle arrest via activating p38 MAPK and inhibiting JNK.
- P38 and JNK have opposing effects on FZD-induced S phase cell cycle arrest.