Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen

► CP31398, SHetA2 and PI were negative in the Ames test and in the mouse bone marrow micronucleus test. ► CP31398 and SHetA2 were negative for chromosomal aberrations (CA) in CHO cells. ► PI was negative in the absence of S9 and positive in the presence of S9 for CA in CHO cells. ► Induction of CA with PI in the presence of S9 may be due to the metabolites generated in cultures. ► All 3 compounds may be potential chemopreventive agents for further development.